Subbu Insights · Precision Intravenous Anaesthesia

TCI–TIVA,
made intuitive

One place to learn intravenous anaesthesia end-to-end — a guided pathway, a full simulator cockpit, and focused labs for every concept. Don't just read the kinetics: move the sliders, predict what happens, then check yourself. Everything runs in your browser. No login, no data collected.

Start the Learning Pathway → Browse the tools ↓
★ Start here · the spine of it all

The TCI / TIVA Learning Pathway

A guided, hands-on route from the three-compartment model to running a complete intravenous anaesthetic — six levels, each with an aim, a guided exploration, and a challenge to attempt before you reveal the answer. Progress is saved on your device.

01The three compartments 02Plasma vs effect-site 03Marsh · Schnider · Eleveld 04Bolus speed & the plasma peak 05Depth, BIS & emergence 06Capstone — a full anaesthetic

How the tools map to the journey

Every simulator below powers a specific level of the pathway.

L1
The three compartments
Three-Compartment Model · Marsh animated sim — below
L2
Plasma vs effect-site
Propofol TIVA Simulator (plasma / effect targeting) — the cockpit
L3
Marsh · Schnider · Eleveld
TIVA Simulator · Model Comparison · Volume Explorer
L4
Bolus speed & the plasma peak
Bolus-Speed Lab — focused labs
L5
Depth, BIS & emergence
TIVA Simulator (BIS & pause-review) · Context-Sensitive Half-Time
L6
Capstone — a full anaesthetic
Propofol TIVA Simulator — run it end to end
01

Foundations — the concepts

Build the intuition the models and the pump depend on.

Pathway · Level 1

The Three-Compartment Model New

Why the plasma curve has three phases

Give one IV bolus and watch the plasma level peak and fall through its rapid, intermediate and slow phases as the drug fills the blood, vessel-rich and fat/muscle tanks.

  • Animated bolus with live compartment tanks
  • Log-scale sampling reveals three exponentials
  • The empirical origin of the tri-exponential curve
Open simulator →
Pathway · Level 5

Context-Sensitive Half-Time New

Why recovery depends on how long you infused

Compare propofol, remifentanil and fentanyl. Change the infusion duration and see why terminal elimination half-life alone badly misleads at the bedside.

  • Compare up to three drugs at once
  • Live recovery curves after stopping
  • CSHT-vs-duration plot and data table
Open simulator →
02

The cockpit — the complete simulator

Where every concept comes together in one tool.

Pathway · Levels 2 · 3 · 5 · 6

Propofol TIVA Simulator

Plasma & effect-site kinetics, mapped to tissues

The full cockpit: run Marsh, Schnider or Eleveld with manual, plasma- or effect-site targeting; watch the distribution map fill, the concentration–time curves diverge, and predicted BIS respond — then pause and scrub back through the whole anaesthetic.

  • Manual · TCI-plasma · TCI-effect modes
  • Marsh / Schnider / Eleveld with live covariates
  • Effect-site (ke₀) & deliberate plasma overshoot
  • Predicted BIS depth & burst-suppression band
  • Pause → review scrubber across the whole case
Open the simulator ↗
03

Focused labs — one concept each

Short, single-idea tools to drill a specific point.

Pathway · Level 4

Propofol Bolus-Speed Lab

How injection speed shapes the plasma peak

Vary how fast an induction bolus is given and watch the plasma peak slide down while the effect-site peak barely moves — speed buys plasma risk, not hypnotic depth.

  • Adjustable push speed and dose
  • Plasma vs effect-site peak comparison
  • Companion clinical guide included
Open the lab →
Pathway · Level 3

Model Comparison

Marsh, Schnider & Eleveld, side by side

Run all three population models at once with independent TCI controllers. Change the patient and watch the curves separate — and Schnider's LBM warning appear at high BMI.

  • Three parallel live simulations
  • Patient sliders: age, weight, height, sex
  • Calculated PK parameter table
Launch comparison →
Pathway · Level 1

Marsh Animated 3-Compartment

The classic Diprifusor, visualised

Animated drug particles flowing between blood, muscle and fat, with live concentrations, infusion rate and a bolus function — the original animated sim.

  • Live Cp, Ce, C₂, C₃ readouts
  • Target Cp control (0.5–8 µg/mL)
  • mg/kg/hr · mL/hr display
Launch simulation →
Pathway · Level 3

Compartment Volume Explorer

How V₁ · V₂ · V₃ differ across models

A dedicated visual comparison of how the compartment volumes differ across the three models — animated tanks, proportional bubbles and bar charts that update instantly.

  • Liquid-fill tanks proportional to volume
  • Bubble chart — area ∝ volume
  • LBM warning for Schnider in obesity
Launch explorer →
04

Reference — the evidence base

Every parameter, cross-checked against primary literature.

Supports all levels

Bibliography & Key Data

15 references · confirmed equations

All 15 references with confirmed parameter equations, side-by-side comparison tables, clinical implications, and the Marsh V₁ correction note. Print-ready with one click.

  • 15 formatted references with DOIs
  • Confirmed volume equations (Absalom 2009)
  • Schnider LBM safety warning
Open bibliography →
⚠ Educational use only. These simulations and the learning pathway are designed for anaesthesia teaching, conceptual illustration and intuition-building. They are not intended for clinical decision-making, patient dosing, or therapeutic guidance. The TCI controllers are educational illustrations, not pump-certified algorithms. All parameters derive from published population data; individual responses vary. Always refer to current institutional protocols, drug monographs, and clinical judgement.
SM
Dr Subramanyam S. Mahankali Director of Anaesthesia Services · KIMS Hospitals, Bengaluru — Mahadevapura & Electronic City
TCI · TIVA · Precision Anaesthesia · EEG/BIS Monitoring · AI in Healthcare · AOTTA