Interactive pharmacokinetic simulations for anaesthesia teaching — Marsh, Schnider and Eleveld three-compartment models with live drug distribution, compartment volumes, and infusion rates.
Each tool runs entirely in your browser — no login, no data collection, fully offline-capable once loaded.
The classic Diprifusor model — animated drug particles flowing between blood, muscle and fat. Live concentration bars, infusion rate in mg/kg/hr and mL/hr, bolus function.
Marsh, Schnider and Eleveld running simultaneously with independent TCI controllers. Adjust patient parameters and watch how differently each model responds.
Dedicated visual comparison of how V₁, V₂ and V₃ differ across the three models — animated tanks, proportional bubbles, and bar charts that update instantly with patient parameters.
All 15 references with confirmed parameter equations, comparison tables, clinical implications, and a correction note on the Marsh V₁ value. Print-ready with one click.
Professionally formatted Word document — all equations, parameter tables, clinical implications, the Marsh V₁ correction, and all 15 bibliography entries. Distribute to delegates.
Three ways to use these tools live in a lecture or workshop.
Open the tool in Chrome or Edge. Press F11 for full screen. Alt+Tab between your slides and the simulation seamlessly.
In PowerPoint, right-click any shape → Hyperlink → paste the tool URL. One click launches it during your presentation.
Send delegates this page. They can run every simulation on their own devices during your talk for hands-on learning.
Try changing patient age to 75 years in the comparison tool — watch Schnider's V₂ shrink while Marsh ignores age entirely. Powerful demonstration.
Educational use only. These simulations are designed for anaesthesia teaching and pharmacokinetic illustration. They are not intended for clinical decision-making, patient dosing, or therapeutic guidance. All pharmacokinetic parameters are derived from published population data. Individual patient responses will vary. Always refer to current institutional protocols, drug monographs, and clinical judgement for patient care decisions.
Three-compartment pharmacokinetic models underpin every TCI pump used in modern anaesthesia — yet most clinicians have never seen them visualised in a way that builds genuine intuition. The Marsh, Schnider and Eleveld models behave very differently depending on patient characteristics, and understanding why requires seeing the compartments fill and empty, the infusion rate respond, and the concentrations diverge in real time.
These tools were built over a series of teaching sessions to address that gap. Every parameter has been cross-referenced against primary publications — Marsh (1991), Schnider (1998/1999), Eleveld (2018) — and the key review by Absalom et al. (2009) which confirmed the critical Marsh V₁ = 0.228 × weight equation, not the 4.27 L fixed value that appears erroneously in some educational materials.
Subbu Insights is the thought-leadership and education platform of Dr Subramanyam S. Mahankali, a senior anaesthesiologist, academic editor, and clinical innovator with nearly three decades of experience in perioperative medicine and TCI–TIVA practice.
Full bibliography with all 15 references, DOIs, PMIDs and annotations available in the Bibliography tool above.